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beta(2) glycoprotein-I inhibits factor XII activation on triglyceride rich lipoproteins: The effect of antibodies from plasma of patients with antiphospholipid syndrome

McNally, T; Mackie, IJ; Isenberg, DA; Machin, SJ; (1996) beta(2) glycoprotein-I inhibits factor XII activation on triglyceride rich lipoproteins: The effect of antibodies from plasma of patients with antiphospholipid syndrome. THROMB HAEMOSTASIS , 76 (2) 220 - 225.

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Abstract

It is now well recognised that antiphospholipid antibodies are associated with thrombosis and recurrent fetal loss. Some antiphospholipid antibodies (aPAs) have been shown to require a cofactor, beta(2) glycoprotein-I (beta(2)GPI), for binding to phospholipids, and recently beta(2)GPI has been identified as the antigenic target for some aPAs. beta(2)GPI possesses in vitro anticoagulant properties and modulation of beta(2)GPI function may therefore result in altered haemostatic regulation. In the present study, the influence of plasma derived aPAs and beta(2)GPI on factor XII activation on the surface of very low density lipoprotein (VLDL) was investigated. Factor XIIa generation was dependent on lipoprotein lipase treatment of VLDL and beta(2)GPI inhibited the factor XIIa generation in a concentration dependent manner. No consistent effects on factor XIIa generation were demonstrated with the IgG fractions from patients with aPAs. inhibition of the beta(2)GPI activity was demonstrated by some antibodies, and study with cardiolipin affinity purified antibody indicated that antibody concentration is critical. These results suggest that perturbation of beta(2)GPI function may contribute to the pathogenic mechanism for thrombosis in some patients with aPAs.

Type: Article
Title: beta(2) glycoprotein-I inhibits factor XII activation on triglyceride rich lipoproteins: The effect of antibodies from plasma of patients with antiphospholipid syndrome
Keywords: BETA-2-GLYCOPROTEIN-I, COAGULATION, BETA(2)-GLYCOPROTEIN-I, AUTOACTIVATION, CARDIOLIPIN, DEFICIENCY, PLATELETS, BINDING, ASSAY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/85251
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