UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The association of factor VIIa, factor XIIa and beta(2)-glycoprotein-1 with triglyceride-rich lipoproteins in normolipidaemic subjects

Cardigan, RA; Donohoe, S; Purdy, G; Mackie, IJ; Machin, SJ; (1998) The association of factor VIIa, factor XIIa and beta(2)-glycoprotein-1 with triglyceride-rich lipoproteins in normolipidaemic subjects. BLOOD COAGUL FIBRIN , 9 (4) 323 - 332.

Full text not available from this repository.

Abstract

The activation of factors XII (FXII) and VII (FVII) has been shown to occur on the surface of lipoproteins in the presence of lipoprotein lipase and may be modulated by beta(2)glycoprotein-1 (beta(2)GP1). In the postprandial state FVII is activated without apparent activation of FXII in plasma. We investigated whether beta(2)GP1, FXIIa and FVIIa are associated with triglyceride-rich lipoproteins in the fasting and postprandial state. Six normal subjects were studied while fasting and 1, 2 and 4 h after ingestion of 100 g fat. We confirmed that plasma FVIIa activity, but not FXIIa antigen, was increased in the postprandial period. FXIIa, FVIIa and beta(2)GP1 were associated with chylomicra-rich lipoproteins, and lipase or Triton X-100 treatment caused an increase in FXIIa in plasma and chylomicra without an increase in FVIIa. This suggests that FXIIa may be formed in the postprandial period, but its antigenic determinants are masked by the association with lipoprotein particles, although it could still express proteolytic activity. Alternatively a FXII-independent mechanism or surface other than triglyceride-rich lipoproteins may be responsible for FVII activation in the postprandial state. Blood Coag Fibrinol 9:323-332 (C) 1998 Lippincott-Raven Publishers.

Type: Article
Title: The association of factor VIIa, factor XIIa and beta(2)-glycoprotein-1 with triglyceride-rich lipoproteins in normolipidaemic subjects
Keywords: lipoprotein, factor XIIa, factor VIIa, beta(2)-glycoprotein-1, postprandial lipaemia, COAGULATION-FACTOR-VII, ISCHEMIC HEART-DISEASE, ACTIVATED FACTOR-VII, PLASMA FACTOR-VII, GLYCOPROTEIN-I, PRIMARY HYPERLIPIDEMIA, ALIMENTARY LIPEMIA, HAGEMAN-FACTOR, BETA-2-GLYCOPROTEIN-I, DEFICIENCY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/85239
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item