Central nervous system control of cardiovascular function: Neural mechanisms and novel modulators.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY.
(pp. 743 - 747).
1, Studies are described that indicate that hypothalamic stimulation, at sites eliciting the defence reaction, results in an increase in adenosine levels in both the nucleus tractus solitarius (NTS) and rostral ventrolateral medulla (RVLM) of the rat.2, Adenosine receptor antagonists applied to these sites attenuate the presser response elicited by hypothalamic stimulation, Adenosine appears to be produced extracellularly from ATP,which is released from axon terminals in both the NTS and RVLM.3, The implications of these observations for the pharmacology of hypothalamic actions on reflex inputs that modify cardiorespiratory function are discussed.
|Title:||Central nervous system control of cardiovascular function: Neural mechanisms and novel modulators|
|Event:||Australian-Physiological-and-Pharmacological-Society Symposium on Central Autonomic Regulation|
|Keywords:||adenosine, ATP, blood pressure, hypothalamus, NUCLEUS-TRACTUS-SOLITARIUS, DEFENSE AREA STIMULATION, ROSTRAL VENTROLATERAL MEDULLA, ADENOSINE RECEPTORS, HYPOTHALAMIC-STIMULATION, ANESTHETIZED CAT, BRAIN-STEM, RAT, NEURONS, INHIBITION|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
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