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HEART FATTY-ACID-BINDING PROTEIN IS A NOVEL REGULATOR OF CARDIAC MYOCYTE HYPERTROPHY.
BIOCHEM BIOPH RES CO
1822 - 1828.
Heart fatty acid binding protein (H-FABP) is a 15kDa protein that mediates the passage of fatty acids from the plasma membrane to sites of lipid synthesis. We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis and c-jun expression. A high affinity receptor for H-FABP has also been identified. Taken together, these data suggest that H-FABP may participate in the regulation of cardiac myocyte growth and differentiation. (C) 1994 Academic Press, Inc.
|Title:||HEART FATTY-ACID-BINDING PROTEIN IS A NOVEL REGULATOR OF CARDIAC MYOCYTE HYPERTROPHY|
|Keywords:||GROWTH INHIBITOR MDGI, STIMULATION, DNA|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
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