BURTON, PBJ and HOGBEN, CE and JOANNOU, CL and CLARK, AGB and HSUAN, JJ and TOTTY, NF and SORENSEN, C and EVANS, RW and TYNAN, MJ (1994) HEART FATTY-ACID-BINDING PROTEIN IS A NOVEL REGULATOR OF CARDIAC MYOCYTE HYPERTROPHY. BIOCHEM BIOPH RES CO , 205 (3) 1822 - 1828.
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Abstract
Heart fatty acid binding protein (H-FABP) is a 15kDa protein that mediates the passage of fatty acids from the plasma membrane to sites of lipid synthesis. We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis and c-jun expression. A high affinity receptor for H-FABP has also been identified. Taken together, these data suggest that H-FABP may participate in the regulation of cardiac myocyte growth and differentiation. (C) 1994 Academic Press, Inc.
| Type: | Article |
|---|---|
| Title: | HEART FATTY-ACID-BINDING PROTEIN IS A NOVEL REGULATOR OF CARDIAC MYOCYTE HYPERTROPHY |
| Keywords: | GROWTH INHIBITOR MDGI, STIMULATION, DNA |
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