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HEART FATTY-ACID-BINDING PROTEIN IS A NOVEL REGULATOR OF CARDIAC MYOCYTE HYPERTROPHY

BURTON, PBJ; HOGBEN, CE; JOANNOU, CL; CLARK, AGB; HSUAN, JJ; TOTTY, NF; ... TYNAN, MJ; + view all (1994) HEART FATTY-ACID-BINDING PROTEIN IS A NOVEL REGULATOR OF CARDIAC MYOCYTE HYPERTROPHY. BIOCHEM BIOPH RES CO , 205 (3) 1822 - 1828.

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Abstract

Heart fatty acid binding protein (H-FABP) is a 15kDa protein that mediates the passage of fatty acids from the plasma membrane to sites of lipid synthesis. We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis and c-jun expression. A high affinity receptor for H-FABP has also been identified. Taken together, these data suggest that H-FABP may participate in the regulation of cardiac myocyte growth and differentiation. (C) 1994 Academic Press, Inc.

Type:Article
Title:HEART FATTY-ACID-BINDING PROTEIN IS A NOVEL REGULATOR OF CARDIAC MYOCYTE HYPERTROPHY
Keywords:GROWTH INHIBITOR MDGI, STIMULATION, DNA

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