UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

C-11-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy

Koepp, MJ; Richardson, MP; Labbe, C; Brooks, DJ; Cunningham, VJ; Ashburner, J; VanPaesschen, W; ... Duncan, JS; + view all (1997) C-11-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. NEUROLOGY , 49 (3) 764 - 773.

Full text not available from this repository.

Abstract

Background: Using statistical parametric mapping and C-11-flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) due to hippocampal sclerosis (HS). The limited spatial resolution of PET, however, results in partial-volume averaging that affects quantitative analysis of cBZR density. Method: We determined hippocampal volume loss and reduction in cBZR binding using an MRI-based method for partial-volume effect: correction of C-11-FMZ volume of distribution (FMZ-Vd) in 17 patients with refractory mTLE and an MRI diagnosis of HS that was subsequently histologically verified in all cases. Quantitative neuropathology was performed with assessment of neuron density in 14 of the 17 patients. Absolute FMZ-Vd and asymmetry indices (FMZ-AI) were compared before and after partial-volume effect correction with MRI-determined hippocampal volumes (HCV), hippocampal T-2 measurements, and, if available, neuronal cell densities. Results: Compared with 15 age-matched healthy volunteers, significant reductions of absolute hippocampal FMZ-Vd were found before correction for partial-volume effects in 11 of 17 patients (65%) and only abnormal FMZ-AI in the other six patients. After partial-volume effect correction all 17 patients (100%) showed both significant unilateral reduction of absolute FMZ-Vd and abnormal FMZ-AI. There was no correlation between corrected absolute FMZ-Vd and HCV or neuronal cell density. After correction for partial-volume effect we found a mean 38% reduction of FMZ-Vd in the sclerosed hippocampus, over and above the reduction of HCV. Conclusion: Correction for partial-volume effect allows absolute quantitation of FMZ-PET and increases its sensitivity for detecting abnormalities in TLE due to HS, The lack of correlation between cBZR binding and neuronal density implies that atrophy with neuron loss is not the sole determinant of reduced cBZR binding in patients with mTLE and hippocampal sclerosis.

Type: Article
Title: C-11-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy
Keywords: POSITRON EMISSION TOMOGRAPHY, BENZODIAZEPINE RECEPTORS, HIPPOCAMPAL SCLEROSIS, C-11 FLUMAZENIL, BINDING, BRAIN, HYPOMETABOLISM, METABOLISM, INVIVO, FOCI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/83458
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item