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Placental transport rather than maternal concentration of amino acids regulates fetal growth in monochorionic twins: Implications for fetal origin hypothesis

Bajoria, R; Sooranna, SR; Ward, S; D'Souza, S; Hancock, M; (2001) Placental transport rather than maternal concentration of amino acids regulates fetal growth in monochorionic twins: Implications for fetal origin hypothesis. AM J OBSTET GYNECOL , 185 (5) 1239 - 1246.

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Abstract

OBJECTIVE: The cause of discordant growth in monochorionic twins Is not clear. We hypothesize that growth restriction of 1 monochorionic twin is due to fetal under-nutrition.STUDY DESIGN: We measured plasma amino acid concentrations by high performance liquid chromatography in maternal venous and fetal umbilical cord venous blood samples that were collected at birth from gestational age-matched monochorionic twins (n = 14) with a birth weight discordance of greater than or equal to 20%. The concordant monochorionic twins with birth weight differences of greater than or equal to 10% constitute a control group.RESULTS: In the intrauterine growth-restricted twins, fetal concentrations of essential amino acids valine (P < .01), leucine (P < .01), isoleucine (P < .01), phenylalanine (P <0.1), and L-arginine (P < .05) were lower than the co-twins and concordant monochorionic twin pairs. Fetal concentrations of the nonessential amino acids taurine (P < .001), serine (P < .01), glycine (P < .01), tyrosine (P < .01), and aspartic acid (P < .01) were lower in the intrauterine growth-restricted twin than the co-twin or concordant monochorionic twins. No such differences were found between concordant monochorionic twin pairs. Maternal amino acid concentrations were similar between discordant and concordant groups.CONCLUSION: Concentrations of certain essential and nonessential amino acids in the intrauterine growth-restricted twins were lower than the co-twins. These differences support the hypothesis that intrauterine growth-restriction that affects 1 of the monochorionic twins is due to the impaired placental transport of amino acids rather than intertwin transfusion of blood.

Type: Article
Title: Placental transport rather than maternal concentration of amino acids regulates fetal growth in monochorionic twins: Implications for fetal origin hypothesis
Keywords: monochorionic twins, discordant growth, fetal amino acid concentration, BLOOD-PRESSURE, BIRTH-WEIGHT, RESTRICTION, PREGNANCY, LEUCINE, RETARDATION, ASSOCIATION, TAURINE, COHORT, CELLS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Reproductive Health
URI: http://discovery.ucl.ac.uk/id/eprint/82114
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