UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Discordant fetal leptin levels in monochorionic twins with chronic midtrimester twin-twin transfusion syndrome

Sooranna, SR; Ward, S; Bajoria, R; (2001) Discordant fetal leptin levels in monochorionic twins with chronic midtrimester twin-twin transfusion syndrome. PLACENTA , 22 (5) 392 - 398.

Full text not available from this repository.

Abstract

The objective of this study was to determine the plasma leptin concentrations in monochorionic twin fetuses with and without twin-twin transfusion syndrome (TTTS). Paired maternal and fetal blood samples were obtained at birth from monochorionic twin pregnancies complicated with (n=12)or without TTTS (n=12). Amniotic fluid samples were also collected from twin pairs at amnioreduction and/or fetal blood sampling in utero. Plasma and amniotic fluid leptin concentrations were measured by radio-immunoassay. Fetal leptin levels in the growth-restricted donor were lower than the recipient twin of the TTTS group (Delta mean 3.7; CI 2.6 to 4.7 ng/ml; P <0.001). Fetal leptin levels were comparable between non-TTTS twin pairs (Delta mean 0.9; CI 0.1 to 1.4 ng/ml; P=0.10) and recipient twins of TTTS (P=NS). Maternal plasma concentrations of leptin were comparable between the two groups and were higher than the fetal levels. There was a positive association between cord leptin levels and birthweight of twin pairs (y=0.002x-0.37; r=0.58; P <0.01; n=48). A significant positive. relation was also found between delta leptin levels and percentage discordance in birthweight in the TTTS group (y=0.25x-2.21; r=0.82; P <0.001, n=12). In conclusion, leptin levels in the recipient twins were three times higher than their growth restricted donor twins. However further studies are warranted to elucidate the underlying mechanism. (C) 2001 Harcourt Publishers Ltd.

Type: Article
Title: Discordant fetal leptin levels in monochorionic twins with chronic midtrimester twin-twin transfusion syndrome
Keywords: CORD-BLOOD LEPTIN, SERUM LEPTIN, BIRTH-WEIGHT, INTRAUTERINE GROWTH, PLACENTAL LEPTIN, VASCULAR ANATOMY, PLASMA LEPTIN, AMNIOTIC-FLUID, FULL-TERM, NEWBORNS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Reproductive Health
URI: http://discovery.ucl.ac.uk/id/eprint/82112
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item