UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Intracellular magnesium movements and lymphocyte activation

Rijkers, GT; Henriquez, N; Griffioen, AW; (1993) Intracellular magnesium movements and lymphocyte activation. pp. 205-213.

Full text not available from this repository.
Type: Article
Title: Intracellular magnesium movements and lymphocyte activation
Additional information: Rijkers, G T Henriquez, N Griffioen, A W Review England Magnesium research : official organ of the International Society for the Development of Research on Magnesium Magnes Res. 1993 Sep;6(3):205-13. Activation of lymphocytes through ligation of the antigen receptor complex initiates activation of phospholipase C-gamma (PLC). Activated PLC hydrolyses phosphatidylinositol-4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (InsP3). InsP3 mediates the release of Ca2+ from intracellular stores into the cytoplasm, while InsP4 and InsP3 mobilize extracellular Ca2+. Both processes contribute to the temporary increase in [Ca2+]i that is observed after lymphocyte activation. Because of the availability of Mg(2+)-sensitive and specific fluorochromes like Mag-indo-1 it is now possible to monitor potential changes in [Mg2+]i. In lymphocytes that have responded to receptor activation with high [Ca2+]i, an increase in [Mg2+]i can be found. The [Mg2+]i is in the range that enables it to modulate the activity of a number of cellular enzymes, including key enzymes in the PLC transmembrane signalling pathway. It can be speculated that a differential Mg2+ mobilization response will have consequences for the ultimate cellular response to receptor activation.
Keywords: Calcium/metabolism Cell Membrane/metabolism GTP-Binding Proteins/physiology Humans *Lymphocyte Activation Magnesium/*metabolism Phosphatidylinositols/metabolism Protein-Tyrosine Kinases/metabolism Signal Transduction Type C Phospholipases/metabolism
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Pathology
URI: http://discovery.ucl.ac.uk/id/eprint/81596
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item