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THE 4G/5G GENETIC-POLYMORPHISM IN THE PROMOTER OF THE PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) GENE IS ASSOCIATED WITH DIFFERENCES IN PLASMA PAI-1 ACTIVITY BUT NOT WITH RISK OF MYOCARDIAL-INFARCTION IN THE ECTIM STUDY

YE, S; GREEN, FR; SCARABIN, PY; NICAUD, V; BARA, L; DAWSON, SJ; HUMPHRIES, SE; ... CAMBIEN, F; + view all (1995) THE 4G/5G GENETIC-POLYMORPHISM IN THE PROMOTER OF THE PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) GENE IS ASSOCIATED WITH DIFFERENCES IN PLASMA PAI-1 ACTIVITY BUT NOT WITH RISK OF MYOCARDIAL-INFARCTION IN THE ECTIM STUDY. THROMB HAEMOSTASIS , 74 (3) 837 - 841.

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Abstract

We have investigated the interrelationships of plasma PAI-1 activity, the PAI-1 4G/5G polymorphism and risk of myocardial infarction (MI) in the ECTIM study, a case-control study of MI based in Belfast, Lille, Strasbourg and Toulouse. Mean PAI-1 levels in cases were similar across all centres but in controls, levels in the French centres were significantly higher. Only in Belfast were PAI-1 levels higher in cases (11.7 AU/ml) than controls (10.5 AU/ml). The PAI-1 4G allele frequency was similar in cases and controls (0.55 and 0.54). In all groups, 4G homozygotes had the highest mean plasma PAI-1 level (4G4G vs 5G5G; cases overall: 14.2 vs 12.1 AU/ml; controls overall: 15.0 vs 12.6 AU/ml), with the heterozygotes generally intermediate. The data from Belfast are consistent with the literature implicating PAI-1 level as an MI risk factor. In ECTIM, the PAI-1 4G/5G polymorphism is not a genetic risk factor for MI but is associated with PAI-1 activity. Thus homozygosity for the 4G allele may predispose to elevated PAI-1 and impaired fibrinolysis, perhaps requiring interaction with other genetic or environmental factors to influence MI risk.

Type: Article
Title: THE 4G/5G GENETIC-POLYMORPHISM IN THE PROMOTER OF THE PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) GENE IS ASSOCIATED WITH DIFFERENCES IN PLASMA PAI-1 ACTIVITY BUT NOT WITH RISK OF MYOCARDIAL-INFARCTION IN THE ECTIM STUDY
Keywords: CORONARY-ARTERY DISEASE, FAST-ACTING INHIBITOR, ENDOTHELIAL-CELLS, MESSENGER-RNA, T-PA, RAPID INHIBITOR, EXPRESSION, FIBRINOLYSIS, TRIGLYCERIDE, PLATELET
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/815425
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