Trevisol-Bittencourt, PC; Sander, JW; Silvado, CS; Wittig, EO; (1991) Ketoconazole in the treatment of cryptococcosis of the central nervous system. Arquivos de neuro-psiquiatria , 49 (2) 208 - 210. 10.1590/S0004-282X1991000200016.
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Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day as monotherapy for six months without interruption and both responded. One month after KTZ therapy was withdrawn, however, a relapse of the infection was seen in one case. Side-effects were minimal during the trial of treatment. KTZ could be a useful drug in some cases of neurocryptococcosis.
|Title:||Ketoconazole in the treatment of cryptococcosis of the central nervous system.|
|Open access status:||An open access publication. A version is also available from UCL Discovery.|
|Additional information:||All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Clinical and Experimental Epilepsy|
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