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The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs

Shotton, HR; Clarke, S; Lincoln, J; (2003) The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. DIABETES , 52 (1) 157 - 164.

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Abstract

The aim of the study was to investigate antioxidant (alpha-lipoic acid [LA]) and gamma-linolenic acid treatments in the prevention of changes in autonomic nerves induced in streptozotocin-diabetic rats. Autonomic nerves supplying the heart, penis, and gut were examined using immunohistochemical and biochemical techniques. LA and T-linolenic acid (present in evening primrose oil [EPO]) were administered as dietary supplements (similar to80 and 200 mg (.) kg(-1) (.) day(-1), respectively). LA treatment prevented the diabetes-induced decrease of norepinephrine (NA) in the heart and of type I nitric oxide synthase (NOS-I) expression in erectile tissue of the penis but failed to prevent diabetes-induced changes in NA-, vasoactive intestinal polypeptide-, or calcitonin gene-related peptide-containing nerves supplying the ileum. LA partially prevented and EPO totally prevented the increase in NOS-I activity induced by diabetes in the ileum. EPO treatment failed to prevent any other diabetes-induced changes in the heart, penis, or ileum. These results demonstrate that, whereas LA treatment is more effective than EPO in preventing diabetes-induced changes in autonomic nerves, the effectiveness of LA treatment varies with the target organ studied. Diabetes-induced changes in nerves supplying the ileum are more resistant to treatment than those of the heart and penis.

Type: Article
Title: The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs
Keywords: ALPHA-LIPOIC ACID, VASOACTIVE INTESTINAL POLYPEPTIDE, NITRIC-OXIDE SYNTHASE, GAMMA-LINOLENIC ACID, MAJOR PELVIC GANGLION, EVENING PRIMROSE OIL, OXIDATIVE STRESS, BLOOD-FLOW, MYENTERIC PLEXUS, ENTERIC NERVES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/8105
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