UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Nucleoside analogue use before and during highly active antiretroviral therapy and virus load rebound

Phillips, A; Ledergerber, B; Lundgren, J; Hogg, B; Monforte, AD; Castelli, F; Walker, S; ... Collaboration HIV Cohorts, ; + view all (2004) Nucleoside analogue use before and during highly active antiretroviral therapy and virus load rebound. In: JOURNAL OF INFECTIOUS DISEASES. (pp. 675 - 687). UNIV CHICAGO PRESS

Full text not available from this repository.

Abstract

Patients who use nucleoside reverse-transcriptase inhibitors (NRTIs) before highly active antiretroviral therapy (HAART) have an increased rate of virus rebound. Study of rebound according to specific NRTIs used might inform which NRTIs retain activity once others have failed. We focused on 2280 patients who had received zidovudine and either didanosine or lamivudine before starting HAART, started HAART that included zidovudine with didanosine or lamivudine or stavudine with didanosine or lamivudine, and had virus loads <500 copies/mL within 24 weeks. In a Cox model, the relative hazard (RH) of virus rebound for having switched from zidovudine to stavudine (vs. retaining zidovudine) was 0.94 (95% confidence interval [CI], 0.77-1.15), which suggests little or no benefit in terms of reduced rebound rate. Having switched from didanosine to lamivudine, or vice versa, was associated with a reduced rebound rate (RH, 0.59 [95% CI, 0.48-0.73]), which suggests that these drugs retain appreciable activity after use of the other and of zidovudine.

Type: Proceedings paper
Title: Nucleoside analogue use before and during highly active antiretroviral therapy and virus load rebound
Event: 2nd Conference on HIV Pathogenesis and Treatment
Location: Paris, FRANCE
Dates: 2003-07-13 - 2003-07-16
Keywords: PROTEASE INHIBITOR, CROSS-RESISTANCE, VIROLOGICAL RESPONSE, INFECTED PERSONS, VIRAL RESPONSE, PRIOR EXPOSURE, ZIDOVUDINE, LAMIVUDINE, STAVUDINE, FAILURE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/80877
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item