Behboudi, S; Chao, D; Klenerman, P; Austyn, J; (2000) The effects of DNA containing CpG motif on dendritic cells. IMMUNOLOGY , 99 (3) 361 - 366.
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Dendritic cells (DC) are specialized antigen-presenting cells. DC can acquire and process antigens in the periphery before maturing and migrating to secondary lymphoid tissues where they present the antigens and deliver co-stimulatory signals to T cells. We describe an immunostimulatory oligonucleotide containing a CpG motif that stimulated murine DC to up-regulate co-stimulatory molecules, induce T-cell proliferative responses and secrete interleukin-12 in vitro. Administration of this oligonucleotide, but not of a control oligonucleotide lacking this motif, to mice led to the disappearance of DC from the marginal zone and T-cell areas of spleen, but not from heart or kidney. The same CpG did not cause maturation of monocyte-derived human DC in vitro, but lipopolysaccharide-treated monocyte-derived DC showed enhanced functional activity and up-regulated co-stimulatory molecules.
|Title:||The effects of DNA containing CpG motif on dendritic cells|
|Keywords:||ADJUVANTS, OLIGODEOXYNUCLEOTIDES, IMMUNIZATION, GENERATION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
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