UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The effects of DNA containing CpG motif on dendritic cells

Behboudi, S; Chao, D; Klenerman, P; Austyn, J; (2000) The effects of DNA containing CpG motif on dendritic cells. IMMUNOLOGY , 99 (3) 361 - 366.

Full text not available from this repository.

Abstract

Dendritic cells (DC) are specialized antigen-presenting cells. DC can acquire and process antigens in the periphery before maturing and migrating to secondary lymphoid tissues where they present the antigens and deliver co-stimulatory signals to T cells. We describe an immunostimulatory oligonucleotide containing a CpG motif that stimulated murine DC to up-regulate co-stimulatory molecules, induce T-cell proliferative responses and secrete interleukin-12 in vitro. Administration of this oligonucleotide, but not of a control oligonucleotide lacking this motif, to mice led to the disappearance of DC from the marginal zone and T-cell areas of spleen, but not from heart or kidney. The same CpG did not cause maturation of monocyte-derived human DC in vitro, but lipopolysaccharide-treated monocyte-derived DC showed enhanced functional activity and up-regulated co-stimulatory molecules.

Type:Article
Title:The effects of DNA containing CpG motif on dendritic cells
Keywords:ADJUVANTS, OLIGODEOXYNUCLEOTIDES, IMMUNIZATION, GENERATION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

Archive Staff Only: edit this record