Anderson, JC; McDermott, BP; Griffin, EJ; (2000) Asymmetric epoxide cyclisation route to the F-pyran fragment of the altohyrtins and key aldol studies. TETRAHEDRON , 56 (44) 8747 - 8767.
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The evolution of an asymmetric synthesis of a differentially protected F-pyran ring of the altohyrtins is described, which relies on a key intramolecular cyclisation of a C-43 hydroxyl group onto a C-38-C-39 epoxide. The C-38-C-39 epoxide stereochemistry was achieved through optimisation of substrate control. Key aldol studies towards coupling the F-pyran ring with an E-pyran ring precursor was investigated, but unsuccessful. (C) 2000 Elsevier Science Ltd. All rights reserved.
|Title:||Asymmetric epoxide cyclisation route to the F-pyran fragment of the altohyrtins and key aldol studies|
|Keywords:||asymmetric synthesis, epoxidation, aldol reactions, pyran, SPONGE HYRTIOS-ALTUM, POTENT CYTOTOXIC MACROLIDES, MARINE SPONGE, ENANTIOSELECTIVE SYNTHESIS, C SPONGISTATIN-2, STEREOSELECTIVE CONSTRUCTION, ABSOLUTE STEREOSTRUCTURES, CONVERGENT APPROACH, ALLYLIC ALCOHOLS, SUBUNIT|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry|
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