Steric and electronic limitations for the Dotz benzannulation of aromatic alkynes.
3849 - 3852.
As part of an investigation into a new strategy for biaryl synthesis, the Dotz benzannulation of a series of substituted aryl acetylenes was undertaken to deterinine possible steric and electronic effects exerted by the aryl group. In the ortho position it was found that methyl, methoxy, chloro N-amide substituents give moderate to good yields of product. whereas carbonyl derivatives and the nitro group are deleterious. (C) 2002 Published by Elsevier Science Ltd.
|Title:||Steric and electronic limitations for the Dotz benzannulation of aromatic alkynes|
|Keywords:||biaryls, alkynes, Dotz reactions, quinones, FISCHER CARBENE COMPLEXES, CONVERGENT SYNTHESIS, BIARYL SYNTHESIS, DERIVATIVES, ACETYLENES, CARBONYLATION, CONSTRUCTION, ALDEHYDES, WATER, BOND|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry|
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