DOBLER, M; ANDERSON, JC; JUCH, M; BORSCHBERG, HJ; (1995) SYNTHESIS OF ARISTOTELIA-TYPE ALKALOIDS .15. TOTAL SYNTHESIS OF (+)-HOBARTINOL. HELV CHIM ACTA , 78 (2) 292 - 300.
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Synthetic (+)-makomakine (6) was transformed in six steps into (+)-(17R,18R)-17,18-dihydrohobartine-17,18-diol ((+)-5) with an overall yield of 38% (Scheme 2). This compound was shown to be identical with natural hobartinol, a monoterpene indole alkaloid from Aristotelia australasica, originally believed to be the (17S)-epimer 1. At the same time, the synthesis of (+)-5 delineates the hitherto unknown absolute configuration of this metabolite.
|Title:||SYNTHESIS OF ARISTOTELIA-TYPE ALKALOIDS .15. TOTAL SYNTHESIS OF (+)-HOBARTINOL|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry|
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