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Local field potentials and spikes in the human medial temporal image lobe are selective to image category

Kraskov, A; Quiroga, RQ; Reddy, L; Fried, I; Koch, C; (2007) Local field potentials and spikes in the human medial temporal image lobe are selective to image category. J COGNITIVE NEUROSCI , 19 (3) 479 - 492.

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Abstract

Local field potentials (LFPs) reflect the averaged dendrosomatic activity of synaptic signals of large neuronal populations. In this study, we investigate the selectivity of LFPs and single neuron activity to semantic categories of visual stimuli in the medial temporal lobe of nine neurosurgical patients implanted with intracranial depth electrodes for clinical reasons. Strong selectivity to the category of presented images was found for the amplitude of LFPs in 8% of implanted microelectrodes and for the firing rates of single and multiunits in 14% of microelectrodes. There was little overlap between the LFP- and spike-selective microetectrodes. Separate analysis of the power and phase of LFPs revealed that the mean phase was category-selective around the theta frequency range and that the power of the LFPs was category-selective for high frequencies around the gamma rhythm, Of the 36 microelectrodes with amplitude-selective LFPs, 30 were found in the hippocampus. Finally, it was possible to readout information about the category of stimuli presented to the patients with both spikes and LFPs. Combining spiking and LFP activity enhanced the decoding accuracy in comparison with the accuracy obtained with each signal alone, especially for short time intervals.

Type: Article
Title: Local field potentials and spikes in the human medial temporal image lobe are selective to image category
Keywords: HUMAN HIPPOCAMPAL-FORMATION, HUMAN EXTRASTRIATE CORTEX, COMPLEX VISUAL-STIMULI, NEURONAL-ACTIVITY, HUMAN BRAIN, DIFFERENCE POTENTIALS, EVOKED-POTENTIALS, FACE PERCEPTION, PARIETAL CORTEX, WORKING-MEMORY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/79743
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