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THE EFFECT OF FLUID-JET MIXING ON PROTEIN PRECIPITATE GROWTH DURING LOW-FREQUENCY CONDITIONING

TITCHENERHOOKER, NJ; HOARE, M; MCINTOSH, RV; FOSTER, PR; (1992) THE EFFECT OF FLUID-JET MIXING ON PROTEIN PRECIPITATE GROWTH DURING LOW-FREQUENCY CONDITIONING. CHEM ENG SCI , 47 (1) 75 - 86.

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Abstract

The mixing effects of low-frequency conditioning during protein precipitate aggregation are investigated. The conditioning process is described on the basis of a jet-mixing phenomena with aggregation being enhanced by the mixing effect of a fluid jet formed during vibration. The mixing performance is shown to correlate with the frequency of formation and the amplitude of the fluid jet. This amplitude is determined by the response of the conditioning system to a pulse or disturbance and is, for a particular suspending fluid, a function of the geometry of the outlet pipe of the conditioning chamber. The fluid-jet acceleration determines the break-up or prevention of formation of large precipitate aggregates. Improvements in the precipitate particle size distribution are related to the extent of fluid-jet mixing which promotes the removal of fine particles by aggregation with larger particles. Maxima are observed in particle size enhancement as a function of the fluid-jet acceleration with up to 40% increase in particle size at the fine end of the cumulative size distribution.

Type: Article
Title: THE EFFECT OF FLUID-JET MIXING ON PROTEIN PRECIPITATE GROWTH DURING LOW-FREQUENCY CONDITIONING
Keywords: SEPARATION, FLOW, SHEAR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Engineering Science Faculty Office
URI: http://discovery.ucl.ac.uk/id/eprint/78623
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