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Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis

Beirne, P; Pantelidis, P; Charles, P; Wells, AU; Abraham, DJ; Denton, CP; Welsh, KI; ... Kelleher, P; + view all (2009) Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis. EUR RESPIR J , 34 (6) 1376 - 1382. 10.1183/09031936.00028209.

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Abstract

Multiplex protein technology has the potential to identify biomarkers for the differentiation, classification and improved understanding of the pathogenesis of interstitial lung disease. The aim of this study was to determine whether a 30-inflammatory biomarker panel could discriminate between healthy controls, sarcoidosis and systemic sclerosis (SSc) patients independently of other clinical indicators. We also evaluated whether a panel of biomarkers could differentiate between the presence or absence of lung fibrosis in SSc patients.We measured 30 circulating biomarkers in 20 SSc patients, 21 sarcoidosis patients and 20 healthy controls using Luminex bead technology and used Fisher's discriminant function analysis to establish the groups of classification mediators.There were significant differences in median concentration measurements between study groups for 20 of the mediators but with considerable range overlap between the groups, limiting group differentiation by single analyte measurements. However, a 17-analyte biomarker model correctly classified 90% of study individuals to their respective group and another 14-biomarker panel correctly identified the presence of lung fibrosis in SSc patients.These findings, if they are corroborated by independent studies in other centres, have potential for clinical application and may generate novel insights into the modulation of immune profiles during disease evolution.

Type: Article
Title: Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis
DOI: 10.1183/09031936.00028209
Keywords: Chemokines, cytokines, fibrosis, growth factors, sarcoidosis, scleroderma, INTERSTITIAL LUNG-DISEASES, PULMONARY SARCOIDOSIS, INTERFERON-GAMMA, CYTOKINE, INTERLEUKIN-12, ALPHA, AUTOIMMUNITY, INVOLVEMENT, SCLERODERMA, CHEMOKINES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/78371
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