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Pharmacological preconditioning of primary rat cardiac myocytes by FK506

Cumming, DVE; Heads, RJ; Coffin, RS; Yellon, DM; Latchman, DS; (1996) Pharmacological preconditioning of primary rat cardiac myocytes by FK506. BASIC RES CARDIOL , 91 (5) 367 - 373.

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Abstract

Pre-treatment with the immunosuppressant FK506 is shown to protect primary cardiocytes against a subsequent severe thermal or ischaemic stress. This effect is not observed with the related compounds cyclosporin A or rapamycin. It does not involve induction of the FK506 binding, heat inducible protein hsp56 or of the other heat shock proteins. In addition over-expression of hsp56 does not protect cardiac cells from severe stress in contrast to our previous results with hsp70 and hsp90. These results suggest the FK506 is acting via a novel mechanism to protect cardiac cells against cellular ischaemia which may not be related to its immunosuppressant action.

Type:Article
Title:Pharmacological preconditioning of primary rat cardiac myocytes by FK506
Keywords:FK506, cellular ischemia, immunosuppressant action, HEAT-SHOCK RESPONSE, STRESS PROTEIN, MYOCARDIAL PROTECTION, ISCHEMIC-INJURY, MYOGENIC CELLS, EXPRESSION, RABBIT, REPERFUSION, RESISTANCE, RECOVERY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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