Mensah, K and Mocanu, M and Yellon, DM (2006) Atorvastatin reduces infarct size in an isolated rat heart model by activating pro-survival kinases. In: Kimchi, A, (ed.) Advances in Heart Disease. (pp. 325 - 329). MEDIMOND S R L
Full text not available from this repository.
Abstract
Statins activate the PI3-kinase/Akt pathway, the pro-survival pathway. We therefore hypothesized that statins could reduce infarct size if used as a preconditioning mimetic. Isolated rat hearts were stabilized for 35 minutes on a Langerndoff apparatus during which time they received 50 mu mol atorvastatin for 10 minutes followed by 10 minutes of washout prior to ischemia/reperfusion, (Group 2). There were 3 further groups; Group I received 10 minutes of vehicle followed by washout; Group 3 received atorvastatin with wortmannin, the PI3-kinase inhibitor, and Group 4 received wortmannin alone. Atorvastatin was found to reduce infarct size significantly, infarct to risk (I/R) ratio decreasing from 44.3%+/- 2.5% to 22.2%+/- 6.6%. This protective effect was abrogated by the PI3K inhibitor wortmannin I/R ratio 53.0% +/- 2.6%). Wortmannin had no effect on infarct size (I/R ratio 58.0%+/- 6.3%). Atorvastatin given as a preconditioning mimetic reduces infarct via the PI3-kinase signalling pathway.
| Type: | Proceedings paper |
|---|---|
| Title: | Atorvastatin reduces infarct size in an isolated rat heart model by activating pro-survival kinases |
| Event: | 12th World Congress on Heart Disease |
| Location: | Vancouver, CANADA |
| Dates: | 2005-07-16 - 2005-07-19 |
| ISBN-13: | 978-88-7587-192-5 |
| Keywords: | NITRIC-OXIDE SYNTHASE, REPERFUSION, AKT, ANGIOGENESIS, STATINS |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
Archive Staff Only: edit this record