Mensah, K; Mocanu, M; Yellon, DM; (2006) Atorvastatin reduces infarct size in an isolated rat heart model by activating pro-survival kinases. In: Kimchi, A, (ed.) Advances in Heart Disease. (pp. 325 - 329). MEDIMOND S R L
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Statins activate the PI3-kinase/Akt pathway, the pro-survival pathway. We therefore hypothesized that statins could reduce infarct size if used as a preconditioning mimetic. Isolated rat hearts were stabilized for 35 minutes on a Langerndoff apparatus during which time they received 50 mu mol atorvastatin for 10 minutes followed by 10 minutes of washout prior to ischemia/reperfusion, (Group 2). There were 3 further groups; Group I received 10 minutes of vehicle followed by washout; Group 3 received atorvastatin with wortmannin, the PI3-kinase inhibitor, and Group 4 received wortmannin alone. Atorvastatin was found to reduce infarct size significantly, infarct to risk (I/R) ratio decreasing from 44.3%+/- 2.5% to 22.2%+/- 6.6%. This protective effect was abrogated by the PI3K inhibitor wortmannin I/R ratio 53.0% +/- 2.6%). Wortmannin had no effect on infarct size (I/R ratio 58.0%+/- 6.3%). Atorvastatin given as a preconditioning mimetic reduces infarct via the PI3-kinase signalling pathway.
|Title:||Atorvastatin reduces infarct size in an isolated rat heart model by activating pro-survival kinases|
|Event:||12th World Congress on Heart Disease|
|Dates:||2005-07-16 - 2005-07-19|
|Keywords:||NITRIC-OXIDE SYNTHASE, REPERFUSION, AKT, ANGIOGENESIS, STATINS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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