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RETINOIC ACID AND LIMB REGENERATION

BROCKES, JP; (1990) RETINOIC ACID AND LIMB REGENERATION. JOURNAL OF CELL SCIENCE 191 - 198.

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Abstract

A key problem in the study of vertebrate development is to determine the molecular basis of positional value along a developmental axis. In amphibian regeneration, retinoic acid is able to respecify positional value in a graded fashion that is dependent on its concentration. In view of the fact that retinoic acid is a naturally occurring metabolite of vitamin A, this raises the possibility that it is deployed in vivo as an endogenous morphogen. Furthermore, the recent evidence that its effects are mediated by nuclear receptors of the steroid/thyroid hormone of its graded effects on morphogenesis. Such insights would be of crucial importance for our understanding of vertebrate patterning along as axis.

Type: Article
Title: RETINOIC ACID AND LIMB REGENERATION
Location: MANCHESTER, ENGLAND
Keywords: MORPHOGEN, HOMEOBOX GENES, AXIS SPECIFICATION, NUCLEAR RECEPTOR, MORPHOGENESIS, SPATIAL-DISTRIBUTION, PATTERN-FORMATION, AMPHIBIAN LIMB, RECEPTOR, EXPRESSION, IDENTIFICATION, CELLS, ACTIVATION, GENES, BUD
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/77927
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