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Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2

Devine, MJ; Lewis, PA; (2008) Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. FEBS J , 275 (23) 5748 - 5757. 10.1111/j.1742-4658.2008.06707.x.

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Abstract

The last decade has seen clear links emerge between the genetic determinants and neuropathological hallmarks of parkinsonism and dementia, notably with the discovery of mutations in alpha-synuclein and tau. Following the description of mutations in LRRK2 linked to Parkinson's disease, characterized by variable pathology including either alpha-synuclein or tau deposition, it has been suggested that LRRK2 functions as an upstream regulator of Parkinson's disease pathogenesis. This minireview explores this model, in the context of our current understanding of the biochemistry of LRRK2, alpha-synuclein and tau.

Type:Article
Title:Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2
DOI:10.1111/j.1742-4658.2008.06707.x
Keywords:alpha-synuclein, Lewy bodies, LRRK2, MAPT, neurofibrillary tangles, paired helical filament, Parkinson's disease, ROCO protein, SNCA, tau, ALPHA-SYNUCLEIN, KINASE-ACTIVITY, TAU GENE, NEURODEGENERATIVE DISEASE, NEUROFIBRILLARY TANGLES, ALZHEIMERS-DISEASE, NEURONAL TOXICITY, ROC DOMAIN, MUTATIONS, LEUCINE-RICH-REPEAT-KINASE-2
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience

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