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Measurement of surface roughness of tablets made from polyethylene glycol powders of various molecular weight

Podczeck, F; (1998) Measurement of surface roughness of tablets made from polyethylene glycol powders of various molecular weight. Pharmacy and Pharmacology Communications , 4 (4) pp. 179-182.

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Abstract

Laser profilometry has been used to study the possibility of surface damage to tablets as a result of a friability test. Polyethylene glycol powders of various molecular weight were used as model substances. The surface roughness of the tablets before testing was found to be a linear function of the brittleness of the materials expressed as the critical stress intensity factor. The type of surface damage was, however, more related to the softness of the surfaces formed. Surfaces of softer materials were damaged by a knocking-off of asperity tips, while harder, more brittle materials were damaged by breaking of the asperities at their points of connection to the surface. In general it was found that surfaces of tablets made from powders with a higher resistance to crack propagation were less liable to surface damage during a friability test.

Type: Article
Title: Measurement of surface roughness of tablets made from polyethylene glycol powders of various molecular weight
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/763766
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