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THE APPLICATION OF CANONICAL-ANALYSIS TO THE EVALUATION OF THE INFLUENCE OF CHANGES IN COMPONENTS OF STANDARD DIRECT COMPRESSION TABLET FORMULATIONS

PODCZECK, F; MERKEL, G; REVESZ, P; (1993) THE APPLICATION OF CANONICAL-ANALYSIS TO THE EVALUATION OF THE INFLUENCE OF CHANGES IN COMPONENTS OF STANDARD DIRECT COMPRESSION TABLET FORMULATIONS. INT J PHARM , 97 (1-3) 15 - 28.

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Abstract

Different types of microcrystalline and microfine celluloses are often used in direct tabletting mixtures. An evaluation has been undertaken of the connection between the pharmaceutical behaviour of a range of the cellulose products and the powder and tablet properties of the tabletting mixtures, using the multivariate statistical technique of canonical analysis. The cellulose properties were reflected in the behaviour of the tabletting mixtures, in particular the bulk volume, the particle size range, the formation energy (force-displacement-curves, E2) and the elastic recovery energy (E3). The approach demonstrated that an exchange of the cellulose product in direct tabletting mixtures is only possible in special cases.

Type:Article
Title:THE APPLICATION OF CANONICAL-ANALYSIS TO THE EVALUATION OF THE INFLUENCE OF CHANGES IN COMPONENTS OF STANDARD DIRECT COMPRESSION TABLET FORMULATIONS
Keywords:MULTIVARIATE STATISTICAL ANALYSIS, CANONICAL ANALYSIS, CELLULOSE POWDER, DIRECT COMPRESSION, BASIC MIXTURE, PHARMACEUTICAL TECHNOLOGY, MULTIVARIATE MATHEMATICAL TECHNIQUES, ORAL DOSAGE FORMS, LUBRICANTS
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Mechanical Engineering

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