THE EVALUATION OF A 3-DIMENSIONAL SHAPE FACTOR FOR THE QUANTITATIVE ASSESSMENT OF THE SPHERICITY AND SURFACE-ROUGHNESS OF PELLETS.
INT J PHARM
A three-dimensional shape factor for the characterisation of the quality of pellets has been developed based on image analysis. The shape factor includes the separate assessment of deviations from the spherical shape and the presence of surface roughness. These two components can be viewed and compared with the overall three-dimensional shape factor e(c3), which connects the two features. The shape factor e(c3) has been applied to three sets of pellets prepared by extrusion/spheronisation, and a comparison with the Heywood shape factors has been undertaken. The results demonstrate the ability of e(c3) to differentiate various batches of pellets based on a defined mathematics, whereas the Heywood shape factors require certain assumptions about the particle outline to be applicable.
|Title:||THE EVALUATION OF A 3-DIMENSIONAL SHAPE FACTOR FOR THE QUANTITATIVE ASSESSMENT OF THE SPHERICITY AND SURFACE-ROUGHNESS OF PELLETS|
|Keywords:||IMAGE ANALYSIS, PARTICLE SHAPE, PELLET, SPHERICITY, SURFACE ROUGHNESS|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > School of BEAMS > Faculty of Engineering Science
UCL > School of BEAMS > Faculty of Engineering Science > Mechanical Engineering
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