UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The characterization of the mechanical strength of chewable tablets.

Ambros, MC; Podczeck, F; Podczeck, H; Newton, JM; (1998) The characterization of the mechanical strength of chewable tablets. Pharm Dev Technol , 3 (4) pp. 509-515. 10.3109/10837459809028633.

Full text not available from this repository.

Abstract

The purpose of this research was to identify possible test procedures for the evaluation of the strength of chewable tablets with respect to prevention of damage to teeth or mandibular joints when tablets are consumed. Diametral compression and flexure tests were employed to evaluate the strength of commercial samples from five manufacturers of chewable vitamin C tablets. Weibull analysis was used to assess the brittleness of these tablets. The tablets had a lower tensile strength value when determined by the diametral compression test compared to the flexure test ratio which ranged from 0.27 to 0.4. The value for the Weibull modulus ranged from 5 to 16, indicating an appreciable degree of brittleness of the samples. Relating the values for the mechanical strength to suggested practical values for the prevention of damage to the teeth or the mandibular joints indicated that most tablets exceeded these values. The flexure test reflects the practical situation closest, and a limiting tensile strength value of 2 MPa should not be exceeded for chewable tablets. The tablet batches tested were also characterized by a large batch-to-batch variability, suggesting uncontrolled manufacturing procedures. Commercially distributed chewable vitamin C tablets could provide a possible health hazard to teeth and mandibular joints. This hazard could be limited by a mechanical strength test specification.

Type: Article
Title: The characterization of the mechanical strength of chewable tablets.
Location: England
DOI: 10.3109/10837459809028633
Keywords: Mastication, Tablets, Tensile Strength
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/763675
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item