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Association between the rs4880 superoxide dismutase 2 (C > T) gene variant and coronary heart disease in diabetes mellitus

Jones, DA; Prior, SL; Tang, TS; Bain, SC; Hurel, SJ; Humphries, SE; Stephens, JW; (2010) Association between the rs4880 superoxide dismutase 2 (C > T) gene variant and coronary heart disease in diabetes mellitus. DIABETES RES CLIN PR , 90 (2) 196 - 201. 10.1016/j.diabres.2010.07.009.

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Abstract

Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C>T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to examine the association between this variant and coronary heart disease (CHD) risk in a cross-sectional sample of subjects with diabetes.776 Caucasian subjects with diabetes were genotyped. CHD risk, oxidised-LDL and plasma total anti-oxidant status (TAOS) were analysed in relation to genotype. In females, the TT genotype was associated with CHD (CC/CT/TT: No CHD vs. CHD: 22.4/56.0/21.6% vs. 12.0/50.0/38.0%, p = 0.03; for CC/CT vs. TT, p = 0.01). The odds ratio for CHD associated with the IT genotype compared to CC/CT was 2.22 [95%CI: 1.17-4.24], p = 0.01. The TT genotype was also associated with significantly lower plasma TAOS. In males, no association was observed between genotype and CHD risk, but CHD was significantly associated with age, lower HDL, higher triglycerides, higher BMI and cigarette smoking.The TT genotype of this variant is associated with increased CHD risk and lower plasma anti-oxidant defences in females with diabetes. This modest genotype-effect is not apparent in males where traditional risk factors may play a greater role. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Type:Article
Title:Association between the rs4880 superoxide dismutase 2 (C > T) gene variant and coronary heart disease in diabetes mellitus
DOI:10.1016/j.diabres.2010.07.009
Keywords:Superoxide dismutase, Gene variant, Oxidative stress, Diabetes, CHD, rs4880, Mitochondria, Total anti-oxidant status, OXIDATIVE STRESS, CARDIOVASCULAR-DISEASE, PLASMA MARKERS, RISK, POLYMORPHISM, NEPHROPATHY, ENVIRONMENT, JAPANESE, CANCER, SOD2
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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