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Monocyte and Macrophage Dysfunction as a Cause of HIV-1 Induced Dysfunction of Innate Immunity

Collini, P; Noursadeghi, M; Sabroe, I; Miller, RF; Dockrell, DH; (2010) Monocyte and Macrophage Dysfunction as a Cause of HIV-1 Induced Dysfunction of Innate Immunity. [Review]. Current Molecular Medicine , 10 (8) 727 - 740. 10.2174/156652410792630634.

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Abstract

HIV-1 can establish both long lived and productive infection of macrophages (M phi) but circulating monocytes are less permissive to infection. Multiple studies have identified extensive changes to monocyte and M phi phenotype, differentiation or function. These include alterations in Toll-like receptor signaling and resultant changes to cytokine responses, specific defects in phagocytosis and microbial killing and modulation of apoptotic responses, all of which may perturb the important role of these cells in innate immunity. Interpretation of contradictory data however, is complicated by the use of different experimental models and many of the reported effects may be an indirect consequence of HIV-1 infection that result from exposure to viral products or from disruption of cellular and cytokine networks in the immune system, rather than the direct consequence of productive HIV-1 infection. Future research should focus on refining experimental models and on elucidating the physiological mechanisms of monocyte/M phi dysfunction during HIV-1 infection.

Type: Article
Title: Monocyte and Macrophage Dysfunction as a Cause of HIV-1 Induced Dysfunction of Innate Immunity
DOI: 10.2174/156652410792630634
Publisher version: http://doi.org/10.2174/156652410792630634
Language: English
Keywords: Apoptosis, HIV-1, innate immunity, macrophage, monocyte, phagocytosis
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/762936
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