Ovariectomy vs. Hypofunction: Their Effects on Rat Mandibular Bone.
J DENT RES
615 - 620.
Previous studies have suggested that the mandible may be more influenced by mechanical loading than by circulating hormone levels. We tested the hypothesis that hypofunction has a greater influence than ovariectomy on mandibular bone. Two-month-old rats were ovariectomized (OVX) or had maxillary molars removed from one side to induce unilateral mandibular hypofunction. Control animals remained untreated. After 5 months, animals were killed, and bones were assessed by microtomography (mu CT), quantitative back-scattered electron analysis in an SEM (qBSE-SEM), and light microscopy. Mineralization density was reduced in calvarial, maxillary, and mandibular alveolar bone following OVX, yet was increased in lingual mandibular alveolar bone of the hypofunction animals compared with controls. OVX caused a reduction in osteocyte density in alveolar bone, while hypofunction showed an increase compared with controls. Hypofunction led to alveolar bone becoming more highly mineralized and more cellular, while ovariectomy caused a reduction in both mineralization density and osteocyte numbers.
|Title:||Ovariectomy vs. Hypofunction: Their Effects on Rat Mandibular Bone|
|Keywords:||ovariectomy, hypofunction, osteocyte number, bone density, osteoporosis, alveolar bone, ESTROGEN-RECEPTOR-ALPHA, ALVEOLAR BONE, MINERALIZATION DENSITY, MECHANICAL STRAIN, APPARENT DENSITY, TOOTH EXTRACTION, GROWING RATS, OSTEOPOROSIS, ADAPTATION, DEFICIENCY|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
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