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Hippocalcin: A new solution to an old puzzle

Brown, DA; Lancaster, B; Shah, MM; (2007) Hippocalcin: A new solution to an old puzzle. NEURON , 53 (4) 467 - 468. 10.1016/j.neuron.2007.01.026. Gold open access

Abstract

In hippocampal pyramidal neurons, calcium entry following an action potential burst results in a slow afterhyperpolarization (sAHP) that critically regulates subsequent excitability. Although this potassium current was described two decades ago, the mechanism whereby the rise in intracellular calcium generates the sAHP was, until now, not known. In this issue of Neuron, Tzingounis et al. now show that calcium binding to hippocalcin, a member of the NCS family, is one of the necessary steps involved in production of the sAHP.

Type: Article
Title: Hippocalcin: A new solution to an old puzzle
Open access status: An open access publication
DOI: 10.1016/j.neuron.2007.01.026
Publisher version: http://ukpmc.ac.uk/abstract/MED/17296544
Keywords: CA2+-ACTIVATED K+ CHANNELS, HIPPOCAMPAL-NEURONS, SLOW-AFTERHYPERPOLARIZATION, PHOTOLYTIC MANIPULATION, PROTEIN HIPPOCALCIN, POTASSIUM CHANNELS, PYRAMIDAL NEURONS, SWITCH PROTEIN, ACTIVATION, CELLS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/76011
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