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CYP2D6-DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM IN MULTIPLE SYSTEM ATROPHY

PLANTEBORDENEUVE, V; BANDMANN, O; WENNING, G; QUINN, NP; DANIEL, SE; HARDING, AE; (1995) CYP2D6-DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM IN MULTIPLE SYSTEM ATROPHY. MOVEMENT DISORD , 10 (3) 277 - 278.

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Abstract

Molecular genetic studies of the cytochrome P450 system enzyme CYP2D6, which hydroxylates debrisoquine, have indicated an excess of mutant yaffles in large series of patients with Parkinson's disease (PD) when compared with controls. We have investigated CYP2D6 polymorphism in 91 patients with multiple system atrophy (MSA) in order to determine if this finding is specific to PD or if there is similar evidence of genetic susceptibility to neurotoxicity in MSA. The distribution of CYP2D6 alleles was not significantly different between MSA patients and controls, and there were fewer poor metabolisers in the MSA group than in the control group.

Type:Article
Title:CYP2D6-DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM IN MULTIPLE SYSTEM ATROPHY
Keywords:MULTIPLE SYSTEM ATROPHY, CYTOCHROME P450, PARKINSONS DISEASE, PARKINSONS-DISEASE, DEBRISOQUINE HYDROXYLATION, CYP2D LOCUS, 4-HYDROXYLATION, DEFECT
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology

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