UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Drug treatment of Parkinson's disease.

Quinn, N; (1995) Drug treatment of Parkinson's disease. BMJ , 310 (6979) 575 - 579.

Full text not available from this repository.

Abstract

A wide variety of drugs is available for treating Parkinson's disease, including anticholinergics, amantadine levodopa, dopamine agonists, and selegiline. In younger patients (less than 50) levodopa is usually delayed provided that adequate relief of symptoms can be achieved with other drugs. In older patients (greater than 70) levodopa should be started as soon as symptom relief is required. Between these ages there is no consensus, but at present most such patients should probably be given controlled release levodopa before a dopamine agonist is added. Fluctuations can often be alleviated by giving controlled release preparations of levodopa, by giving small doses at frequent intervals, by adding selegiline or a long acting oral agonist, or by subcutaneous apomorphine. Dyskinesia can be peak dose, diphasic, or "off period." The diphasic form is hardest to alleviate. Psychiatric side effects should initially be managed by changing the antiparkinsonian treatment before resorting to antipsychotic drugs.

Type:Article
Title:Drug treatment of Parkinson's disease.
Location:ENGLAND
Language:English
Additional information:PMCID: PMC2548944
Keywords:Age Factors, Aged, Amantadine, Antiparkinson Agents, Cholinergic Agents, Dopamine Agonists, Humans, Levodopa, Parkinson Disease, Selegiline
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology

Archive Staff Only: edit this record