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The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia

Hutton, SB; Huddy, V; Barnes, TRE; Robbins, TW; Crawford, TJ; Kennard, C; Joyce, EM; (2004) The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. BIOL PSYCHIAT , 56 (8) 553 - 559. 10.1016/j.biopsych.2004.07.002.

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Abstract

Background: Both oculomotor and neuropsychologic deficits have been used to support the hypothesis that schizophrenia is associated with prefrontal cortex dysfunction, but studies that have specifically investigated the relationships between these deficits have produced in consistent findings.Methods: We measured both smooth pursuit and antisaccade performance in a large group (n = 109) of patients with first episode schizophrenia and a group of matched control subjects (n = 59) and investigated the relationship between performance on these tasks and performance on a range of executive tasks. We additionally explored the relationship between these variables and measures of psychopathology at presentation and duration of untreated psychosis.Results: Antisaccade errors were significantly correlated with spatial working memory performance. Smooth pursuit gain did not correlate with any neuropsychologic measure. There were no reliable correlations between either oculomotor variables and measures of psychopathology and duration of untreated,psychosis.Conclusions: These findings suggest that in schizophrenia working memory and antisaccade performance reflect the same abnormal prefrontal substrates and that smooth pursuit is mediated by a separate neural abnormality.

Type: Article
Title: The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia
DOI: 10.1016/j.biopsych.2004.07.002
Keywords: antisaccade, executive function, oculomotor, schizophrenia, smooth pursuit, working memory, CARD SORTING TEST, SACCADIC EYE-MOVEMENT, POSITRON EMISSION TOMOGRAPHY, SPATIAL WORKING-MEMORY, FRONTAL-LOBE LESIONS, TEST-PERFORMANCE, PSYCHOTIC-PATIENTS, PARKINSONS-DISEASE, TASK-PERFORMANCE, BIPOLAR DISORDER
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/7514
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