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Heat stress response and myocardial protection

Joyeux, M; Godin-Ribuot, D; Yellon, DM; Demenge, P; Ribuot, C; (1999) Heat stress response and myocardial protection. FUND CLIN PHARMACOL , 13 (1) 1 - 10.

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Abstract

Prior whole-body hyperthermia is able to protect the myocardium against ischaemia-reperfusion injury by reducing cellular necrosis, preserving the ventricular function and preventing the occurrence of arrhythmias. These cardioprotective effects are associated with reduction of oxidative stress, preservation of the high-energy phosphate levels and synthesis of heat stress proteins. A better understanding of this powerful protective adaptation of the myocytes would be of interest for potential clinical application, and rational design of specific agents that activate this mechanism will hopefully follow soon. (C) Elsevier, Paris.

Type:Article
Title:Heat stress response and myocardial protection
Keywords:heat stress, heat stress protein, myocardium, myocardial protection, POSTISCHEMIC VENTRICULAR RECOVERY, ISCHEMIA-REPERFUSION INJURY, CELLS CONFERS PROTECTION, SHOCK PROTEIN INDUCTION, RAT HEARTS, CARDIAC MYOCYTES, MESSENGER-RNA, RABBIT HEART, BACTERIAL LIPOPOLYSACCHARIDE, FUNCTIONAL RECOVERY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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