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Molecular mechanisms of preconditioning: Therapeutic implications

Bell, RM; Yellon, DM; (1998) Molecular mechanisms of preconditioning: Therapeutic implications. Revista Portuguesa de Cardiologia , 17 (SUPPL. 2) 49 - 61.

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Abstract

Preconditioning the myocardium by brief repeated periods sub-lethal ischaemia evokes powerful endogenous mechanisms of cellular adaptation that can protect the myocardium against subsequent lethal ischaemia. The clinical exploitation of preconditioning in both pathological and surgical situations to ensure myocardial viability is attractive. Expansion in the knowledge of the mechanisms underlying preconditioning has brought us close to the threshold of developing useful therapies. In this review we critically appraise the research that has been thus far performed and review possibilities for the future.

Type:Article
Title:Molecular mechanisms of preconditioning: Therapeutic implications
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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