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Nodal peripheral T-cell lymphomas and, in particular, their lymphoepithelioid (Lennert's) variant are often derived from CD8(+) cytotoxic T-cells

Geissinger, E; Odenwald, T; Lee, SS; Bonzheim, I; Roth, S; Reimer, P; ... Rudiger, T; + view all (2004) Nodal peripheral T-cell lymphomas and, in particular, their lymphoepithelioid (Lennert's) variant are often derived from CD8(+) cytotoxic T-cells. VIRCHOWS ARCH , 445 (4) 334 - 343. 10.1007/s00428-004-1077-2.

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Abstract

Nodal peripheral T-cell lymphomas are not well understood, and most of them are classified in the "not otherwise specified group" (PTCL-NOS). Data on their normal cellular derivation are ambiguous. Most peripheral T-cell lymphomas are composed of tumor cells and a ( sometimes dominant) reactive background, which also includes resting and activated T-lymphocytes. We defined the phenotype of the tumor cells in 101 PTCL-NOS based on their cytological atypia and using immunohistochemical double stains on paraffin sections with CD4/Ki67 and CD8/Ki67. The results were correlated to clinical presentation and outcome. Lineage could be defined in 98 cases (97%). Tumor cells were CD4(+) in 43 cases and CD8(+) in 38. These presented at a younger age but a higher clinical stage compared with the CD4(+) lymphomas. In 15 cases, the atypical cells were CD4(-)CD8(-); two cases were CD4(+) CD8(+). Of 17 lymphoepithelioid (Lennert's) lymphomas, 15 expressed CD8, one each was CD4(+) and CD4(-)CD8(-).

Type:Article
Title:Nodal peripheral T-cell lymphomas and, in particular, their lymphoepithelioid (Lennert's) variant are often derived from CD8(+) cytotoxic T-cells
DOI:10.1007/s00428-004-1077-2
Keywords:T-cell lymphoma, Lennert's lymphoma, immunohistochemistry, clinicopathological correlation, phenotype, NON-HODGKINS-LYMPHOMA, UPDATED KIEL CLASSIFICATION, EPSTEIN-BARR-VIRUS, PROGNOSTIC-SIGNIFICANCE, ZONE LYMPHOMA, EXPRESSION, ASSOCIATION, FEATURES, SPECTRUM, DISEASE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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