Soufan, AT and van den Hoff, MJB and Ruijter, JM and de Boer, PAJ and Hagoort, J and Webb, S and Anderson, RH and Moorman, AFM (2004) Reconstruction of the patterns of gene expression in the developing mouse heart reveals an architectural arrangement that facilitates the understanding of atrial malformations and arrhythmias. Circulation Research , 95 (12) 1207 - 1215.
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Firm knowledge about the formation of the atrial components and of the variations seen in congenital cardiac malformations and abnormal atrial rhythms is fundamental to our understanding of the normal structure of the definitive atrial chambers. The atrial region is relatively inaccessible and has continued to be the source of disagreement. Seeking to resolve these controversies, we made three-dimensional reconstructions of the myocardial components of the developing atrium, identifying domains on the basis of differential expression of myocardial markers, connexin40, and natriuretic precursor peptide A. These reconstructions, made from serial sections of mouse embryos, show that from the outset of atrial development, the systemic and pulmonary veins are directly connected to the atrium. Relative to the systemic junctions, however, the pulmonary venous junction appears later. Our experience shows that three- dimensional reconstructions have three advantages. First, they provide clear access to the combined morphological and molecular data, allowing clarification and verification of morphogenetic concepts for nonmorphological experts and setting the scene for further discussion. Second, they demonstrate that, from the outset, the myocardium surrounding the pulmonary veins is distinct from that clothing the systemic venoatrial junctions. Third, they reveal an anatomical and molecular continuity between the entrance of the systemic venous tributaries, the internodal atrial myocardium, and the atrioventricular region. All these regions are derived from primary myocardium, providing a molecular basis for the observed nonrandom distribution of focal right atrial tachycardias
|Title:||Reconstruction of the patterns of gene expression in the developing mouse heart reveals an architectural arrangement that facilitates the understanding of atrial malformations and arrhythmias|
|Additional information:||WoS ID: 000225641000010 JournalDEC 10878ITCIRC RES|
|Keywords:||10, A, abnormal, ALL, AND, Arrhythmia, CARDIAC, COMPONENT, congenital, development, Differential, DISTINCT, DOMAIN, Embryo, EMBRYOS, EXPERIENCE, EXPRESSION, FOR, GENE, Gene Expression, HEART, IS, JOURNAL, Knowledge, malformation, Malformations, MARKER, MOLECULAR, MOLECULAR-BASIS, MOUSE, MYOCARDIUM, OF, PATTERN, PATTERNS, PEPTIDE, PULMONARY, Pulmonary Veins, reconstruction, REGION, REGIONS, SYSTEMIC, THE, three- dimensional, three-dimensional reconstruction, Veins|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health|
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