UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Structural biology of bacterial secretion systems in gram-negative pathogens--potential for new drug targets.

Durand, E; Verger, D; Rêgo, AT; Chandran, V; Meng, G; Fronzes, R; Waksman, G; (2009) Structural biology of bacterial secretion systems in gram-negative pathogens--potential for new drug targets. Infect Disord Drug Targets , 9 (5) pp. 518-547.

Full text not available from this repository.

Abstract

Gram-negative bacteria have evolved diverse secretion systems/machineries to translocate substrates across the cell envelope. These various machineries fulfil a wide variety of functions but are also essential for pathogenic bacteria to infect human or plant cells. Secretion systems, of which there are seven, utilize one of two secretion mechanisms: (i) the one-step mechanism, whereby substrates are translocated directly from the bacterial-cytoplasm to the extracellular medium or into the eukaryotic-target cell; (ii) the two-step mechanism, whereby substrates are first translocated across the bacterial-inner membrane; once in the periplasm, substrates are targeted to one of the secretion systems that mediate the transport across the outer membrane and the release outside the bacterial cell. This review describes in details the main structural features of these secretion systems. Structural biology offers the possibility to understand the molecular mechanisms at play in the various secretion systems. It also helps to design specifically drugs that can block these machineries and thus attenuate the virulence of pathogenic bacteria.

Type: Article
Title: Structural biology of bacterial secretion systems in gram-negative pathogens--potential for new drug targets.
Location: United Arab Emirates
Keywords: Bacterial Outer Membrane Proteins, Bacterial Proteins, Drug Design, Gram-Negative Bacteria, Humans, Periplasm, Protein Transport, Virulence, Virulence Factors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/73791
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item