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EVIDENCE FOR A PSEUDOAUTOSOMAL LOCUS FOR SCHIZOPHRENIA .2. REPLICATION OF A NONRANDOM SEGREGATION OF ALLELES AT THE DXYS14 LOCUS

DAMATO, T; CAMPION, D; GORWOOD, P; JAY, M; SABATE, O; PETIT, C; ABBAR, M; ... MALLET, J; + view all (1992) EVIDENCE FOR A PSEUDOAUTOSOMAL LOCUS FOR SCHIZOPHRENIA .2. REPLICATION OF A NONRANDOM SEGREGATION OF ALLELES AT THE DXYS14 LOCUS. BRIT J PSYCHIAT , 161 59 - 62.

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Abstract

Because of an association between sexual aneuploidies and schizophrenia, and because schizophrenic siblings have been found to be more often of the same than of the opposite sex, the susceptibility locus for schizophrenia is thought to lie within the pseudoautosomal region of the sex chromosomes. We analysed 33 sibships comprising 18 pairs, 13 tribe, and 2 quartets of affected siblings, and found support for non-random segregation of alleles at the DXYS 1 4 locus in affected siblings. These findings are consistent with the pseudoautosomal hypothesis for schizophrenia and favour a genetic linkage between DXYS 14 and the disease.

Type: Article
Title: EVIDENCE FOR A PSEUDOAUTOSOMAL LOCUS FOR SCHIZOPHRENIA .2. REPLICATION OF A NONRANDOM SEGREGATION OF ALLELES AT THE DXYS14 LOCUS
Keywords: HUMAN SEX-CHROMOSOMES, GENETIC-LINKAGE, REGION, CONCORDANCE, LOCALIZATION, SEQUENCES, FEATURES, DISEASE, PAIRS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/73768
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