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FAILURE TO REPLICATE LINKAGE BETWEEN CHROMOSOME 5Q11-Q13 MARKERS AND SCHIZOPHRENIA IN 28 FAMILIES

CAMPION, D; DAMATO, T; LAKLOU, H; SABATE, O; JAY, M; LEBOYER, M; MALAFOSSE, A; ... MALLET, J; + view all (1992) FAILURE TO REPLICATE LINKAGE BETWEEN CHROMOSOME 5Q11-Q13 MARKERS AND SCHIZOPHRENIA IN 28 FAMILIES. PSYCHIAT RES , 44 (3) 171 - 179.

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Abstract

Sherrington et al. (1988) reported linkage between markers located on the 5q11-q13 region of chromosome 5 and schizophrenia in five Icelandic and two British families. To date, however, all attempts to replicate the initial finding have failed. Using three markers of chromosome 5, we have studied 28 additional French pedigrees. When our data were analyzed both with parametric (i.e., lod scores) and nonparametric methods, we found no evidence of linkage. Thus, we were unable to replicate the earlier report by Sherrington et al.

Type: Article
Title: FAILURE TO REPLICATE LINKAGE BETWEEN CHROMOSOME 5Q11-Q13 MARKERS AND SCHIZOPHRENIA IN 28 FAMILIES
Keywords: GENETIC ANALYSIS, MOLECULAR GENETICS, AFFECTED-PEDIGREE MEMBER METHOD, SUSCEPTIBILITY LOCUS, GENETIC-LINKAGE, PSYCHIATRIC-DISORDERS, COMPLEX DISEASES, LOD SCORE, LOCALIZATION, EXCLUSION, FEATURES, PEDIGREE, DNA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/73767
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