Jalan, R; Sargentoni, J; Coutts, GA; Bell, JD; Rolles, K; Burroughs, AK; Robinson, SDT; (1996) Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models. GUT , 39 (1) 141 - 146.
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Background-In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (P-31 MRS) provides biochemical information about phosphorus metabolism.Aim-To assess P-31 MRS as a prognostic marker in patients with primary biliary cirrhosis (PBC) in relation to the current clinical prognostic models.Patients and Methods-Twenty three patients with PBC of varying functional severity and 16 matched healthy volunteers were studied using in vivo P-31 MRS. Spectra were acquired using a 1.5 T spectroscopy system. Peak area ratios of phosphomonoesters (PME), inorganic phosphate (Pi), and phosphodiesters (PDE) and nucleotide triphosphate (NTP) were calculated. Pugh score, Christensen prognostic index, and R value according to the Mayo model were calculated from the clinical data.Results-The PME/NTP, Pi/NTP, PME/PDE, and PME/Pi ratios and the PME signal height ratio (SHR) were significantly higher, while the PDE/NTP and PDE/SHR were significantly lower in PBC patients compared with healthy volunteers (p<0.01). Significant correlations were seen between PME/Pi ratio and the prognostic index according to Christensen (r=0.63, p<0.001), R value according to the Mayo model (r=0.45, p<0.03), and with the Pugh score (r=0.55, p<0.007).Conclusions-This study shows that PME/Pi ratio obtained from P-31 MRS correlates well with all three of the commonly used models of prognosis in patients with PBC. A longitudinal study with larger number of patients is required to confirm these findings and elucidate the biochemical changes underlying this phenomenon.
|Title:||Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models|
|Keywords:||magnetic resonance spectroscopy, primary biliary cirrhosis, AMINOPYRINE BREATH TEST, DISEASE SEVERITY, LIVER-DISEASE, P-31, PREDICTION, PROPEPTIDE, PROGRESS, INVIVO, SERUM|
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