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Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802].

Arnett, KL; Adams, EJ; Gumperz, JE; Darke, C; Marsh, SG; Gelsthorpe, K; Parham, P; (1995) Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802]. Tissue Antigens , 46 (4) pp. 316-321.

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Abstract

The primary structure of a variant HLA-B8 antigen has been determined by cDNA cloning and sequencing. The variant, B*0802 differs, from the common B*0801 subtype at positions 77-83 of the alpha 1 helix that determine the Bw4 and Bw6 public epitopes. Whereas B*0801 has the common Bw6 motif, B*0802 has the Bw4 motif found in B*13 and B*44 allotypes. Serological analysis of B cell lines expressing B*0802 and of a B*0802 transfectant made with the HLA-A,B negative cell line 721.221 shows that B*0802 reacts with Bw4-specific antibodies, but at a level much lower than expected for Bw4 positive HLA-B allotypes.

Type: Article
Title: Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802].
Location: England
Keywords: Alleles, Amino Acid Sequence, Animals, Antibodies, Monoclonal, B-Lymphocytes, Cell Line, Transformed, Epitopes, Female, HLA-B Antigens, HLA-B8 Antigen, Humans, Male, Molecular Sequence Data, Tumor Cells, Cultured
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/73368
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