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Short- and long-term depression at glutamatergic synapses on hippocampal interneurons by group I mGluR activation

Le Duigou, C; Holden, T; Kullmann, DM; (2011) Short- and long-term depression at glutamatergic synapses on hippocampal interneurons by group I mGluR activation. NEUROPHARMACOLOGY , 60 (5) 748 - 756. 10.1016/j.neuropharm.2010.12.015.

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Abstract

Group I metabotropic glutamate receptors (mGluRs) are expressed by many interneurons of the hippocampus. Although they have been implicated in short- and long-term synaptic plasticity of glutamatergic transmission, their roles in modulating transmission to interneurons are incompletely understood. The selective group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (DHPG) acutely depressed transmission at synapses in the feed-forward inhibitory pathway made by Schaffer collaterals on interneurons in the rat hippocampal CA1 sub-field. DHPG elicited a qualitatively similar depression at synapses made by pyramidal neuron axon collaterals on interneurons in the feedback circuit in stratum oriens. Selective blockers revealed a link from mGluR1 to reversible, and mGluR5 to long-lasting, depression. The acute DHPG-induced depression was consistently accompanied by an elevation in paired-pulse ratio, implying a presynaptic decrease in release probability. However, it was also attenuated by blocking G-protein and Ca2+ signalling within the postsynaptic neuron, arguing for a retrograde signalling cascade. The DHPG-evoked depression was unaffected by antagonists of CB1 and GABA(B) receptors but was occluded when presynaptic P/Q-type Ca2+ channels were blocked. Finally, high-frequency stimulation delivered to an independent conditioning pathway evoked a heterosynaptic reversible depression, which was sensitive to group I mGluR antagonists. Group I mGluRs thus powerfully modulate synaptic excitation of hippocampal interneurons and mediate inter-synaptic cross-talk.This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'. (C) 2010 Elsevier Ltd. All rights reserved.

Type: Article
Title: Short- and long-term depression at glutamatergic synapses on hippocampal interneurons by group I mGluR activation
DOI: 10.1016/j.neuropharm.2010.12.015
Keywords: Hippocampus, Interneuron, Metabotropic glutamate receptors, Presynaptic calcium channels, Heterosynaptic depression, MOSSY FIBER SYNAPSES, METABOTROPIC GLUTAMATE, RECEPTOR ACTIVATION, RAT HIPPOCAMPUS, CA1 REGION, SYNAPTIC-TRANSMISSION, PYRAMIDAL CELLS, G-PROTEINS, AREA CA1, POTENTIATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: http://discovery.ucl.ac.uk/id/eprint/733220
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