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Grey matter correlates of syndromes in schizophrenia - A semi-automated analysis of structural magnetic resonance images

Chua, SE; Wright, IC; Poline, JB; Liddle, PF; Murray, RM; Frackowiak, RSJ; Friston, KJ; (1997) Grey matter correlates of syndromes in schizophrenia - A semi-automated analysis of structural magnetic resonance images. BRIT J PSYCHIAT , 170 406 - 410.

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Abstract

Background Symptoms in schizophrenia cluster into syndromes, each of which may be associated with a particular pattern of cerebral blood flow. We sought to investigate whether these syndromes are also related to neuroanatomical changes.Method A semi-automated method was used to examine structural magnetic resonance images in 12 patients with schizophrenia. The relationship between the relative regional grey matter volume and ratings of the syndromes of psyche motor poverty, disorganisation and reality distortion was investigated.Results There was a significant negative correlation between npsychomo tor poverty score and the relative volume of the left ventro-medial prefrontal grey matter, and a significant positive correlation between disorganisation and the relative volumes of the hippocampus, and the parahippocampal/fusiform gyrus bilaterally.Conclusion The correlation between psychomotor poverty and left prefrontal grey matter volume resembles that previously seen with prefrontal blood flow in the same patients, suggesting that this functional abnormality is related to an underlying anatomical change.

Type: Article
Title: Grey matter correlates of syndromes in schizophrenia - A semi-automated analysis of structural magnetic resonance images
Keywords: MONOZYGOTIC TWINS DISCORDANT, CEREBRAL BLOOD-FLOW, TEMPORAL-LOBE, DISORDER, ABNORMALITIES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/72807
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