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HUMAN FOCAL CEREBRAL-ISCHEMIA - EVALUATION OF BRAIN PH AND ENERGY-METABOLISM WITH P-31 NMR-SPECTROSCOPY

LEVINE, SR; HELPERN, JA; WELCH, KMA; VANDELINDE, AMQ; SAWAYA, KL; BROWN, EE; RAMADAN, NM; ... ORDIDGE, RJ; + view all (1992) HUMAN FOCAL CEREBRAL-ISCHEMIA - EVALUATION OF BRAIN PH AND ENERGY-METABOLISM WITH P-31 NMR-SPECTROSCOPY. RADIOLOGY , 185 (2) 537 - 544.

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Abstract

The authors investigated early human focal ischemia with phosphorus-31 nuclear magnetic resonance spectroscopy at 1.89 T to characterize the temporal evolution and relationship of brain pH and phosphate energy metabolism. Data from 65 symptomatic patients were prospectively studied; none of the patients had had ischemic stroke in the internal carotid artery territory before. Twenty-eight neurologically normal individuals served as control subjects. Serial ischemic brain pH levels indicated a progression from early acidosis to subacute alkalosis. When acidosis was present there was a significant elevation in the relative signal intensity of inorganic phosphate (Pi) and significant reductions in signal intensities of alpha-adenosine triphosphate (ATP) and gamma-ATP compared with those of control subjects. Ischemic brain pH values directly correlated with the relative signal intensity of phosphocreatine (PCr) and the PCr index and inversely correlated with the signal intensity of Pi. There was a general lack of correlation between either ischemic brain pH or phosphate energy metabolism and the initial clinical stroke severity. The data suggest a link between high-energy phosphate metabolism and brain pH, especially during the period of ischemic brain acidosis, and the authors propose that effective acute stroke therapy should be instituted during this period.

Type: Article
Title: HUMAN FOCAL CEREBRAL-ISCHEMIA - EVALUATION OF BRAIN PH AND ENERGY-METABOLISM WITH P-31 NMR-SPECTROSCOPY
Keywords: BRAIN, ISCHEMIA, BRAIN, MR, MAGNETIC RESONANCE (MR), PHOSPHORUS STUDIES, MAGNETIC RESONANCE (MR), SPECTROSCOPY, MAGNETIC-RESONANCE SPECTROSCOPY, BLOOD-FLOW, INTRACELLULAR PH, FOREBRAIN ISCHEMIA, HYDROGEN CLEARANCE, CONCURRENT CHANGES, RAT, STROKE, INFARCTION, ACIDOSIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/72615
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