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Cerebral tissue water spin-spin relaxation times in human neonates at 2.4 Tesla: Methodology and the effects of maturation

Thornton, JS; Amess, PN; Penrice, J; Chong, WK; Wyatt, JS; Ordidge, RJ; (1999) Cerebral tissue water spin-spin relaxation times in human neonates at 2.4 Tesla: Methodology and the effects of maturation. MAGN RESON IMAGING , 17 (9) 1289 - 1295.

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Abstract

Using a 4-echo spin-echo sequence, cerebral T-2 was measured in specific anatomic regions in eleven healthy newborn infants, whose gestational plus postnatal ages (GPAs) lay between 37 and 42 weeks. For a region in the pens, T-2 was 141 +/- 9 ms (mean +/- standard deviation), and no significant dependence upon GPA was seen. In the thalamus mean T-2 was 136 +/- 13 ms, and T-2 demonstrated a significant negative linear dependence upon age (r = 0.690; p < 0.02). In periventricular and frontal regions, mean T-2 were 217 +/- 33, and 228 +/- 32 ms respectively, and more marked negative linear correlations with age were observed (r = 0.833; p < 0.001 and r = 0.722; p < 0.02). For these regions, the rate of T-2 decrease with age appeared to be related to known patterns of myelination. For the parietal region studied, mean T-2 was 204 +/- 34 ms, no significant dependence upon GPA being seen. T-2 shows promise as an objective measure of cerebral development in the perinatal period. (C) 1999 Elsevier Science Inc.

Type: Article
Title: Cerebral tissue water spin-spin relaxation times in human neonates at 2.4 Tesla: Methodology and the effects of maturation
Keywords: cerebral development, myelination, spin-spin relaxation, HYPOXIC-ISCHEMIC ENCEPHALOPATHY, CENTRAL-NERVOUS-SYSTEM, DEVELOPING HUMAN BRAIN, MAGNETIC-RESONANCE, IMMATURE BRAIN, WHITE MATTER, MYELINATION, SEQUENCE, CHILDREN, MRI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/72607
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