Simons, JS and Davis, SW and Gilbert, SJ and Frith, CD and Burgess, PW (2006) Discriminating imagined from perceived information engages brain areas implicated in schizophrenia. NEUROIMAGE , 32 (2) 696 - 703. 10.1016/j.neuroimage.2006.04.209.
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Some of the symptoms of schizophrenia may reflect a difficulty discriminating between information that was perceived from the outside world and information that was imagined. This study used fMRI to examine the brain regions associated with this reality monitoring ability in healthy volunteers, who recollected whether information had previously been perceived or imagined, or whether information had been presented on the left or right of a monitor screen. Recent studies have suggested that schizophrenia may be associated particularly with dysfunction in medial anterior prefrontal cortex, thalamus, and cerebellum. In our data, activation in all three of these regions of interest was significantly greater during recollection of whether stimuli had been perceived or imagined versus recollection of stimulus position. In addition, reduced prefrontal activation was associated with the same misattribution error that has been observed in schizophrenia. These results indicate a possible link between the brain areas implicated in schizophrenia and the regions supporting the ability to discriminate between perceived and imagined information. (c) 2006 Elsevier Inc. All rights reserved.
|Title:||Discriminating imagined from perceived information engages brain areas implicated in schizophrenia|
|Keywords:||functional magnetic resonance imaging (fMRI), episodic memory, executive function, cognitive control, rostral prefrontal cortex, source memory, ANTERIOR PREFRONTAL CORTEX, EPISODIC MEMORY RETRIEVAL, RECOGNITION MEMORY, FUNCTIONAL-ANATOMY, FRONTAL-LOBE, RECOLLECTION, INVOLVEMENT, FMRI, PATHOPHYSIOLOGY, HALLUCINATIONS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience|
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
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