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Computer-aided detection in the United Kingdom National Breast Screening Programme: prospective study

Khoo, L.A.L.; Taylor, P.; Given-Wilson, R.M.; (2005) Computer-aided detection in the United Kingdom National Breast Screening Programme: prospective study. Radiology , 237 (2) pp. 444-449. 10.1148/radiol.2372041362.

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Abstract

Purpose: To evaluate prospectively the recall and cancer detection rates with and without computer-aided detection (CAD) in the United Kingdom National Health Service Breast Screening Programme. Materials and methods: The study had appropriate ethics committee approval. Informed consent was not required; however, patients were informed that their mammograms might be used in research efforts, and all patients agreed to participate. Mammograms obtained in 6111 women (mean age, 58.4 years) undergoing routine screening every 3 years were analyzed with a CAD system. Mammograms were independently double read. Twelve readers participated. Readers recorded an initial evaluation, viewed the CAD prompts, and recorded a final evaluation. Recall to assessment was decided after arbitration. Sensitivities were calculated for single reading, single reading with CAD, and double reading, as a proportion of the total number of cancers detected by using double reading with CAD. Results: A total of 62 cancers were detected in 61 women. CAD prompted 51 (84%) of 61 radiographically detected cancers. Of 12 cancers missed on single reading, nine were correctly prompted; however, seven prompts were overruled by the reader. Sensitivity of single reading was 90.2% (95% confidence interval [CI]: 83.0%, 95.0%), single reading with CAD was 91.5% (95% CI: 85.0%, 96.0%), and double reading without CAD was 98.4% (95% CI: 91.0%, 100%). Cancer detection rate was 1%. Recall to assessment rate was 6.1%, with an increase of 5.8% because of CAD. Average time required, per reader, to read a case was 25 seconds without CAD and 45 seconds with CAD. Conclusion: CAD increases sensitivity of single reading by 1.3%, whereas double reading increases sensitivity by 8.2%.

Type:Article
Title:Computer-aided detection in the United Kingdom National Breast Screening Programme: prospective study
DOI:10.1148/radiol.2372041362
Publisher version:http://dx.doi.org/10.1148/radiol.2372041362
Language:English
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > CHIME

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