UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Long-Term Impact of Acyclovir Suppressive Therapy on Genital and Plasma HIV RNA in Tanzanian Women: A Randomized Controlled Trial

Tanton, C; Weiss, HA; Rusizoka, M; LeGoff, J; Changalucha, J; Baisley, K; Mugeye, K; ... Watson-Jones, D; + view all (2010) Long-Term Impact of Acyclovir Suppressive Therapy on Genital and Plasma HIV RNA in Tanzanian Women: A Randomized Controlled Trial. J INFECT DIS , 201 (9) 1285 - 1297. 10.1086/651696.

Full text not available from this repository.

Abstract

Background. Herpes simplex virus (HSV) suppressive therapy reduces genital and plasma human immunodeficiency virus type 1 (HIV-1) RNA over periods up to 3 months, but the long-term effect is unknown.Methods. A total of 484 HIV-1 and HSV type 2 seropositive Tanzanian women aged 16-35 years were enrolled in a randomized placebo-controlled trial of acyclovir administered at a dosage of 400 mg twice daily. Cervicovaginal lavage and blood samples were collected at 6 months, 12 months, and 24 months for quantification of genital and plasma HIV-1 RNA and genital HSV DNA. Primary outcomes were detection and quantity of cervicovaginal HIV-1 RNA at 6 months.Results. At 6 months, there was little difference between the acyclovir and placebo arms for cervico-vaginal HIV-1 RNA detection (88 [41.3%] of 213 vs 84 [44.0%] of 191; odds ratio [OR], 0.90; 95% confidence interval [CI], 0.60-1.33), HSV DNA detection (20 [9.4%] of 213 vs 22 [11.5%] of 191; OR, 0.80; 95% CI, 0.42-1.51), genital HIV or HSV loads, or plasma HIV-1 RNA load. Estimated median adherence was 91%. There was a suggestion of an impact on cervico-vaginal HIV-1 RNA detection among women with estimated adherence >= 90% (OR, 0.74; 95% CI, 0.50-1.09) when data from all 3 visits were included.Conclusions. Acyclovir administered at a dosage of 400 mg twice daily is unlikely to be a useful long-term intervention to reduce HIV transmission. The lack of effect on HIV may be attributable to suboptimal adherence or treatment regimen.

Type: Article
Title: Long-Term Impact of Acyclovir Suppressive Therapy on Genital and Plasma HIV RNA in Tanzanian Women: A Randomized Controlled Trial
DOI: 10.1086/651696
Keywords: HERPES-SIMPLEX-VIRUS, HUMAN-IMMUNODEFICIENCY-VIRUS, POLYMERASE-CHAIN-REACTION, PLACEBO-CONTROLLED TRIAL, HAEMOPHILUS-DUCREYI, CEREBROSPINAL-FLUID, TREPONEMA-PALLIDUM, TYPE-1 INFECTION, HSV SUPPRESSION, SEX WORKERS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/71928
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item